JAN A. GLINSKI, Ph.D.
Planta Analytica, LLC
3 Kenosia Av.
Danbury, CT 06810
(203) 796-0268
jan@plantaanalytica.com
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EXECUTIVE SUMMARY: A very broad background in natural sciences encompassing medicinal/organic chemistry, natural products isolation and characterization, protein purification, chromatographic methods, and structural characterization methods. Extensive knowledge of biological properties of natural products. Advanced understanding of protective antioxidant mechanisms in biology. Fundamental understanding of pharmacology and clinical trial issues. Thirteen years of R&D experience in drug discovery and drug development areas. Experience with organizing laboratory infrastructure. Experienced directing laboratory staff and managing projects. Implemented technical protocols for an international screening program aimed at discovery of new therapeutically useful natural products (European institutes of Boehringer Ingelheim Pharm.). Successful implementation of novel separation technologies. Consulting experience. Founded Planta Analytica, LLC, a company dedicated to research with botanical subjects, better understanding of pharmacological and biochemical properties of plant metabolites.

EDUCATION:

1979 - Ph.D. in organic chemistry. Thesis: "Total Synthesis of Cassipurine".

Advisor: Prof. J. T. Wrobel, University of Warsaw.

1974 - M.S. in organic chemistry. Thesis: "Structure - Light Absorption

Relationship for Model Purple Photographic Dyes", U. of Warsaw, Poland.

POST-DOCTORAL STUDIES:

1985 – 1987: Research Scientist/Associate, Georgia Institute of Technology, School of Chemistry. Advisors: Profs. James C. Powers and Sheldon W. May.

· Syntheses of multifunctional quaternary amines directed at the reactivation of acetylcholinesterase inhibited with the nerve gas Soman.

· Synthesis of isocoumarin derivatives as potential drugs against emphysema and kinetic determination of their inhibitory properties of human leukocyte elastase (HLE).

1984 – 1985: Research Scientist, Georgia Institute of Technology, School of Chemistry. Advisor: Dr. Leon H. Zalkow.

· Structure elucidation of novel natural products. Enhancement of therapeutic properties by chemical modifications.

· Preparation of novel potent and water-soluble prodrugs of Taxol.

· Application of droplet countercurrent chromatography (DCC) for isolating natural products and for separating complex mixtures of isomeric alkaloids.

· Crystal X-ray analysis used to elucidate unusual structural features in the

crystals of secopyrrolizidine alkaloids with partial N---C=O trans-annular bond.

1981 – 1982: Postdoctoral Fellow, University of Georgia, Athens.

Advisor: Dr. S. W. Pelletier.

· Isolation, structure elucidation and structural modification of the diterpenoid alkaloids from Delphinium and Aconitum genera.

EMPLOYMENT:

2001 - present: Planta Analytica, founder and Chief Scientific Officer. Analytical and general research support for pharmaceutical, agrochemical, cosmectic and nutraceutical industry. Research collaborations in the area of biologically active components of herbs. Isolation of markers and standards for various herbs. Specializing in obtaining high-purity standards for research and quality control.

The company pursues three directions:

· Its own research topics.

· Custom research and analytical services for US and international herbal producers .

· Collaboration with government institutions and academic groups in the area of herbal science, standardization and regulation for the industry.

1987 - 2000, Senior Scientist/Principal Scientist, Departments of Medicinal Chemistry, Analytical Sciences, Pharmaceutics and Clinical Research. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut.

Analytical:

· Advisory support to Medicinal Chemistry in analytical and separation methods (including recommendation for purchasing new instrumentation).

· Managed routine and exotic research projects directed at isolation of active components of mixtures, active contaminants, and also did troubleshooting of anomalous phenomena in screening.

· Developed automated LC/MS systems for high throughput purification and identification of compounds from combinatorial chemistry.

· Developed Supercritical Fluid Chromatography (SFC) for analysis and purification of combinatorial libraries.

· Extensively used HPLC for a wide variety of routine and exotic research projects such as: separation of active components of mixtures, developing protocols for purification of compounds from parallel synthesis and profiling of hits from screening.

· Developed and applied Countercurrent Chromatography methods for isolation of trace quantities of active and labile natural products.

· Developed chiral HPLC methods for analysis and purification of enantiomers.

· Isolated and structurally characterized minor contaminants of BI drugs.

Natural Products:

· Managed Natural Products Program and Laboratory; coordinated all stages of high throughput screening of plant and microbial extracts.

· Contributed to preparing a proposal for an international multicenter-screening program for natural products. Developed and implemented protocols for extraction, bioassay-guided fractionation, isolation of actives, analysis and elimination of the interference caused by "false positives".

· Coordinated all stages of biological evaluation for actives considered for lead status.

· Managed for 18 month investigation of biological properties of triptolide as a candidate for lead status.

· Developed state-of-the-art applications of countercurrent chromatography to non-destructive isolations of active components.

· Structure elucidation of active components of microbial and plant extracts; isolation of several potent natural immunosuppressants in conjunction with various research projects.

· Discovered a new facet of a general anti-infective mechanism of plant defenses that led to a novel environmentally friendly plant protection product (patented and out-licensed technology).

Antioxidants:

· In close collaboration with pharmacology labs conducted experiments that defined antioxidant/anti-inflammatory properties of hypericin (St. John’s Wort) and chlorophyll derivatives, suggesting an important dietary role for the latter compound.

· Designed extensive in vivo experimentation with antioxidant inhibition of oxidative stress in the neutrophil- and xanthine oxidase-driven inflammatory responses.

Proteins:

· Isolation and purification of recombinant HIV reverse transcriptase for the Viramune® project.

· Purification of cell adhesion monoclonal antibodies.

· Preparation of small molecule-protein conjugates for immunization.

· Chemical derivatization of monoclonal antibodies to eliminate antigenicity in vivo.

Clinical Research:

· Development of early Phase I and Phase II protocols for experimental pulmonary drugs.

· Writing of the Clinical Investigator’s Brochure (BILL 284).

· Critical analysis of data from trials of a novel leukotriene receptor antagonist in confrontation with recent literature publications.

· Seminar on LTB₄ receptor action and pharmacological significance.

1979 –1980: Research Scientist, University of Warsaw, Poland. Advisor: Dr. Jerzy T. Wrobel

· Stereo specific synthesis of sulfur-containing alkaloids.

· Syntheses of the sulfur-substituted furan, pyrrole, and pyrrolizidine synthones.

1994-1995: Scientific consultant to Procept, Boston, MA.

1993-2000: Scientific consultant to MicroFlo, Co., a BASF subsidiary.

2001-2002: Consultant to Microsource Discovery Systems, Inc.

2002-present: Consultant to Muro Pharmaceutical (subsidiary of Astra Pharm.)

2002-present: Consultant to Proquisa Agrochemicals.

2002-present: Consultant to Kromaton Technologies, Inc.

1995-present: Reviewer for Journal of Natural Products.

AWARDS:

1980 - Award of the Secretary of Polish Academy of Science.

1969 - Winner of the National Olympic Competition in Chemistry.

Jan A. GLINSKI, Ph.D.

Publications

1. "Total Synthesis of Cassipurine, an Alkaloid of Rhizophoraceae", J.T. Wrobel, J.A.

Glinski, Can. J. Chem. 59, 1101 (1981).

2. "Origin of Oxonitine, a Potassium Permanganate Oxidation Product of Aconitine",

S.W. Pelletier, J.A. Glinski, N.V. Mody, J. Am. Chem. Soc. 104, 4676 (1982).

3. "Unusual Hetisine Rearrangement Products" S.W. Pelletier, J.A. Glinski, K. I.

Varughese, J.A. Maddry, N.V. Mody, Het. 20, 413 (1983).

4. "The Diterpenoid Alkaloids of Delphinium tatsienense Franch", S.W. Pelletier,

J.A. Glinski, B.S. Joshi, Szu-ying Chen, Het. 20, 1347 (1983).

5. "The Structure of Tatsiensine, a Novel C₁₉-Diterpenoid Alkaloid from Delphinium

tatsienense Franch", J.A. Glinski, B.S. Joshi, Szu-ying Chen, S.W. Pelletier,

Tet. Lett. 25, 1211 (1984).

6. "Deltatsine, a New C₁₉-Diterpenoid Alkaloid from Delphinium tatsienense Franch"

B.S. Joshi, J.A. Glinski, Szu-ying Chen, S.K. Srivastava, S.. W. Pelletier,

Het. 20, 2037 (1984).

7. "Synthesis of Pyrrolizidine Alkaloids: Indicine, Intermedine, Lycopsamine, and

Analogues and Their N-Oxides. Potential Antitumor Agents", L.H. Zalkow, J.A. Glinski, L.T. Gelbaum, L.S. McGowan, T.J. Fleischmann, M.M. Gordon,

J. Med. Chem. 28, 687 (1985).

8. "Retronecine and Heliotridine, C₈H₁₃NO₂: Diastereomeric Pyrrolizidine Bases",

L.T. Gelbaum, J.A. Glinski, D. VanDerveer, L.H. Zalkow, Acta Cryst.

C41, 13454 (1985).

9. "Synthesis of Heliotridine and Related Alkaloids", J.A. Glinski, L.H. Zalkow,

Tet. Lett. 26, 2857 (1985).

10. "Diastereoisomeric Epoxides of Heliotridine and Retronecine, C₈H₁₃NO₃",

J.A. Glinski, D. VanDerveer, L.H. Zalkow, Acta Cryst. C42, 1237 (1986).

11. "Molecular Structure of 1b,2b-oxy-2a-bromotrachelanthamidine, C₈H₁₂NO₃Br",

J.A. Glinski, D. VanDerveer, L.H. Zalkow, Acta Cryst. C42, 1237 (1986).

12. "The Structures of Four New C₁₉-Diterpenoid Alkaloids from Aconitum forrestii

Stapf", S.W. Pelletier, B.S. Joshi, Q.-P. Jiang, S.W. Pelletier, Het. 27, 185 (1988).

13. "Hetisine Derivatives, Part 1: Acetylation and Oxidation of Hetisine", J.A. Glinski,

B.S. Joshi, Q. P. Jiang, S.W. Pelletier, Het. 27, 185 (1988).

14. "Hetisine Derivatives, Part 2: Novel Rearrangement of 11-Dehydrohetisine and

2,11-Didehydrohetisine", B.S. Joshi, J.A. Glinski, K.I. Varughese, S.W. Pelletier,

Het. 27, 195 (1988).

15. "Hetisine Derivatives, Part 3. Rearrangement of 11-Acetyl-2,13-di-dehydrohetisine

and 13-Dehydro-2,11-diacetylhetisine", Q.-P. Jiang, J.A. Glinski, B.S. Joshi,

J.A. Maddry, M.G. Newton, S.W. Pelletier, Het. 27, 9925 (1988).

16. "Macrocyclic Pyrrolizidine Alkaloids from Senecio anononymus. Separation of a

Complex Alkaloid Extract Using Droplet Countercurrent Chromatography",

L.H. Zalkow, C.F. Asibal, J.A. Glinski, S.J. Bonetti, L.T. Gelbaum,

D. VanDerveer, G. Powis, J. Nat. Prod. 31, 1520 (1988).

17. "Semisynthetic Pyrrolizidine Alkaloid N-Oxide Antitumor Agents. Esters of

Heliotridine", L.H. Zalkow, J.A. Glinski, L.T. Gelbaum, D. Moore, D. Melder,

G. Powis, J. Med. Chem. 31, 1520 (1987).

18. "Anonamine, C₁₉H₂₇NO₇; Neosenkirkine, C₁₉H₂₇NO₆; Hydroxysenkirkine,

C₁₉H₂₇NO₇.MeOH. Macrocyclic Secopyrrolizidine Alkaloids from Senecio

anonymus Wood", J.A. Glinski, C.F. Asibal, D. VanDerveer, L.H. Zalkow,

Acta Cryst. C44, 1593 (1988).

19. "Pyrrolizidine Alkaloids from Cynoglossum creticum. Synthesis of Pyrrolizidine

Alkaloids Echinatine, Rinderine, and Analogs", C.F. Asibal, J.A. Glinski,

L.T. Gelbaum, L.H. Zalkow, J. Nat. Prod., 52, 109 (1989).

20. "Synthesis of Congeners and Prodrugs. 3. Water-Soluble Prodrugs of Taxol

with Potent Antitumor Activity", H.M. Deutsch, J.A. Glinski, M. Hernandez,

R.D. Haugwitz, V.L. Narayanan, M. Suffness, L.H. Zalkow, J. Med. Chem.

32, 788 (1989).

21. "The Structure and Partial Synthesis of Delelatine, an Alkaloid from Delphinium

Species", S.A. Ross, H.K. Desai, B.S. Joshi, S.K. Srivastava, J.A. Glinski,

S.-Y. Chen, S.W. Pelletier, Phytochemistry 27, 3719 (1988).

22. "Effect of the 7-Amino Substituent on the Inhibitory Potency of Mechanism-Based

Isocoumarin Inhibitors for Porcine Pancreatic and Human Neutrophil Elastases:

A 1.85-Å X-ray Structure of the Complex between Porcine Pancratic Elastase

and 7-[(N-Tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin",

M. Hernandez, J.C. Powers, J.A. Glinski, J. Oleksyszyn, J. Vijayalakshmi,

E.F. Meyer, J. Med. Chem. 35, 1121-1129 (1991).

23. "Screening Natural Products. Bioassay-Directed Isolation of Active Components.",

J.A. Glinski, G.O. Caviness, J.R. Mikell, J. Liq. Chrom. 13, 3625 (1990).

24. "Tatsirine, A Diterpenoid Alkaloid from Delphinium tatsienense Franch",

X. Zhang, J.K. Snyder, B.S. Joshi, J.A. Glinski, S.W. Pelletier Heterocycles

31, 1879 (1990).

25. "Production and Purification of Recombinant HIV-1 and HIV-2 Reverse

Transcriptase: Preparation of Both Homodimeric and Heterodimeric Forms",

T.C. Warren, J.J. Miglietta, J.M. Rose, L. Kopp, K. Lubbe, J.C. Wu, K.A. Cohen,

J.A. Glinski, D.E.H. Palladino, G.O. Caviness, G.C. Chow, S.L. Rogers, P. Farina,

P.M. Grob, Biochem. (1992).

26. "Centrifugal Partition Chromatography in Assay-guided Isolation of

Immunosuppressive Components of Tripterygium wilfordii", J.A. Glinski,

G.O. Caviness, Chapter 6, pp. 133-165, in Handbook of Centrifugal Partition

Chromatography, ed. A. Foucault, M. Dekker (1995).

27. "Inactivation of Cell Surface Receptors by Pheophorbide A, a green pigment

isolated from Psychotria acuminata", J.A. Glinski, E. David, T.C. Warren,

G. Hansen, S.F. Leonard, P. Pitner, S. Pav, R. Arvigo, M.J. Balick, E. Panti,

P.M. Grob, Photochem. Photobiol. 62, 144-150 (1995).

28. “Anti-inflammatory and antioxidant properties of hypericin”, J.A. Glinski,

Diane Thome, Genus Possanza, Randall Barton, (in preparation).

29. “Anti-inflammatory and antioxidant properties of hematin, chlorophyll derivatives,

and phtalocyanins”, J.A. Glinski, Diane Thome, Genus Possanza, Randall Barton,

(in preparation).

30. Anti-inflammatory and antioxidant properties of dyes of diverse structures”,

J.A. Glinski, Diane Thome, Genus Possanza, Randall Barton, (in preparation).

31. “Evaluation of the Natural Product SeaKleen for Controlling the Musty-Odor-Producing Cyanobacterium Oscillatoria perornatana in Catfish Ponds”, K. K. Schrader, A. M. Rimando, C. S. Tucker, J. Glinski, A. J. Cutler and H.G. Cutler, North American Journal of Aquaculture, 66, 20-28 (2004).

Patents

1. U.S. Patent 5,157,049 "Method of Treating cancers Sensitive to Treatment

with Water Soluble Derivatives of Taxol", Oct.20, 1992, R.D. Haugwitz, L.H. Zalkow, J.A. Glinski, H.M. Deutsch, V.L. Narayanan.

2. U.S. Patent 5,089,633, "Substituted Isocoumarins", Feb. 18, 1992, J.C. Powers,

C.-M. Kam, J. Oleksyszyn, J.A. Glinski, M. Hernandez.

3. U.S. Patent 5,206,371 "Quaternary Pyridinium Compounds", Apr. 27, 1993,

J.C. Powers, S.W. May, M.A. Hernandez, S. Thornton, J.A. Glinski.

4. U.S. Patent 5,180,831 "Quaternary Pyridinium Compounds", Jan. 19, 1993,

J.C. Powers, S.W. May, M.A. Hernandez, S. Thornton, J.A. Glinski.

5. U.S. Patent 5,290,942 "Quaternary Pyridinium Compounds and Uses Therefor",

March 1, 1994, J.C. Powers, S.W. May, M.A. Hernandez, S. Thornton, J.A. Glinski.

6. U.S. Patent 5,324,648, "Substituted Isocoumarins as Serine Protease Inhibitors

and Anti-inflammatory Agents", June 28, 1994, J.C. Powers, C.-M. Kam,

J. Oleksyszyn, J.A. Glinski, M. Hernandez.

7. Canadian Patent 1,330,436 "Water Soluble, Antineoplastic Derivatives of Taxol",

June 26, 1994, R.D. Haugwitz, L.H. Zalkow, J.A. Glinski, H.M. Deutsch, V.L. Narayanan.

8. US Patent 6,303,589 “Pentacyclic triterpenes”. J. A. Glinski, K. L. Branly,

Oct. 16, 2001.

9. US Patent 6,433,010 “Pentacyclic triterpenes”, J.A. Glinski, K. L. Branly,

Aug. 13, 2002.

10. US Patent 6,458,834 “Pentacyclic triterpenes”, J.A. Glinski, K. L. Branly,

Oct. 1, 2002.

11. US Patent pending “Hair and Skin Protecting Compositions Based on Esters of

Betulin” , J.A. Glinski, Appl. Oct. 16, 2004.

Papers Presented

1. Polish-Czechoslovakian Symposium on Natural Products, Warsaw, June 1978,

J.T. Wrobel, J.A. Glinski, "Synthesis and Reactions of 1,2-Didehydropyrrolizidine".

2. Polish-Czechoslovakian Symposium on Natural Products, Warsaw, July 1980,

J.T. Wrobel, J.A. Glinski, "Conversion of 1,2-Epoxypyrrolizidines to

1,2-Epithiopyrrolizidines. Stereo-Controlled Cleavage of the Oxiirane Ring".

3. IUPAC 12th International Symposium on Chemistry of Natural Products, Spain,

Aug. 1980, J.T. Wrobel, J.A. Glinski, "Synthesis of Cassipurine".

4. Third IUPAC Symposium on Organic Synthesis, Madison, WI, 1980, J.T. Wrobel,

J.A. Glinski, "Total Synthesis of Cassipurine".

5. Eighth International Symposium on Medicinal Chemistry, Uppsala, Sveden,

Aug. 27-31, 1984, L.H. Zalkow, L.T. Gelbaum, J.A. Glinski, "Semisynthetic

Pyrrolizidine Alkaloid Antitumor Agents".

6. 36th Southern Regional meeting, ACS, Raleigh, NC, October 24-26 1984,

J.A. Glinski, L.H. Zalkow, "Synthesis of Heliotridine and Heliotridine Ester

Alkaloids from Retronecine".

7. American Society for Pharmacology and Experimental Therapeutics, ACS

Symposium, Boston, MA, Aug. 18-22 1985, L.H. Zalkow, J.A. Glinski,

T. Fleishman, T. Fortune, "Semisynthetic Pyrrolizidine Alkaloid Antitumor

Agents".

8. 191st National ACS Meeting, New York, April 1986, L.H. Zalkow, J.A. Glinski,

G. Powis,"Semisynthetic Pyrrolizidine Alkaloid Antitumor Agents. Heliotridine derivatives".

9. 8th Atlanta Chromatography Symposium, Atlanta, GA, June 4 1986, C.F. Asibal,

J.A. Glinski, L.H. Zalkow, "Use of Droplet Countercurrent Chromatography for Separation of Isomeric Pyrrolizidine Alkaloids".

10. Meeting of American Society of Biochemistry, Philadelphia, Aug. 1987,

J.C. Powers, M. Hernandez, J.A. Glinski, C.-M. Kam, J. Oleksyszyn,

"Mechanism-Based Isocoumarin Inhibitors for Human Leukocyte Elastase

and Cathepsin G".

11. International Congress on Natural Products Research, Park City, UT, July 1988,

L.H. Zalkow, C.F. Asibal, J.A. Glinski, S.J. Bonetti, L.T. Gelbaum, D. VanDerveer,

G. Powis, "Macrocyclic Pyrrolizidine Alkaloids from Senecio anonymus".

12. Invited lecture. National Cancer Institute, Frederick, MD, Feb. 9 1989, J.A. Glinski

"Joys and Pitfalls of High Capacity Screening".

13. 50th Meeting of the American Society of Pharmacognosy, San Jose, Puerto Rico,

Aug. 1989, J.A. Glinski, G. Chow, M. Skoog, M. Matteo "Inhibition of Elastase by

Pentacyclic Triterpenes".

14. Proceedings of 1989 Medical Defenses Bioscience Review, Washington, DC,

Aug. 1989, J.C. Powers, M. Hernandez, J.A. Glinski, K. Black "Disubstituted Pyrdinium Salts as Reactivators of Soman-Inactivated Acetylcholinesterase".

15. J.C. Powers, M.A. Hernandez, S.S. Thornton, J. Glinski, B.D. White, Y.Y. Chen,

and S.W. May, "Derivatives of 2-Formyl-1-Methyl-Pyridinium Chloride.

Preparation, In Vitro Inhibition of Acetylcholinesterase and In Vivo Evaluation as

Reactivators and Prophylactic Agents Against Soman Poisoning", 23rd Meeting of

the Department of the Army Medical Defense, July, 1989; Washington D.C.,

pp 721-728

16. Invited lecture. Third International Colloquium on Centrifugal Partition

Chromatography, San Mateo,CA, June 21-22 1990, J.A. Glinski, G.O.

Caviness, J.R. Mikell "Screening Natural Products. Bioassay-directed

Isolation of Active Components".

17. Innovations in Antiviral Development and Detection of Viral Infections,

Philadelphia,Nov.14-15, 1990, T.C. Warren, J.J. Miglietta, J.M. Rose, K. Lubbe,

S.L. Rogers, G.O. Caviness, J.A. Glinski, C-K. Shih, G.C. Chow, K.D. Hargrave,

K.K. Grozinger, J. Adams, P.R. Farina, P.M. Grob, "Preparation of Recombinant

HIV-1 and HIV-2 Reverse Transcriptase: Specificity of Inhibition by a Novel, Non-

nucleoside RT Inhibitor, BI-RG-587.

18. 201st ACS Meeting, Atlanta, April 1991, H.M. Deutsch, L.L. Ernhart, J.A. Glinski,

M.A. Hernandez, R.D. Haugwitz, V.L. Narayanan "Water Soluble Prodrugs of The

Benzene Maleimide Photoadduct Mitindomide as Potential Antitumor Agents".

19. 201st ACS Meeting, Atlanta, April 1991, M.A. Hernandez, S.S. Thornton,

J.A. Glinski, B.D. White, Y-Y. Chen, S.W. May, J.C. Powers, "Prophylactic

Agents and Reactivators Against Poisoning by Soman and Tabun".

20. M.A. Hernandez, S.S. Thornton, J. Glinski, B.D. White, Y.-Y. Chen, S.W. May,

and J.C. Powers, "Prophylactic Agents and Reactivators Against Poisoning by

Soman and Tabun", 201st American Chemical Society Meeting, April 14-19, 1991;

Atlanta, Georgia.

21. International Research Congress on Natural Products, American Society of

Pharmacognosy, Chicago, July 21-26, 1991, J.A. Glinski, P.M. Grob,

T.C. Warren, E. David, J. Proudfoot, . Hansen, S.F. Leonard "Inactivation of

Cell Surface Receptors by Pheophorbide A and Pyropheophorbide A, Natural

Products Isolated from Leaves of Psychotria acuminata.

22. Invited lecture. New England Chromatography Council Symposium, June 26,

1992, Danbury, CT, "Use of Centrifugal Partition Chromatography for the

Isolation of Active Principles from the Chinese Medicinal Plant Tripterygium

wilfordii. G.O. Caviness, J.A. Glinski.

23. Second Joint Meeting of the Phytochemical Societes of Europe/North America,

August 8-12, 1992, Miami Beach, FL, "Use of Centrifugal Partition Chromatography for the Isolation of Triptolide and Tripdiolide from the Chinese Medicinal Plant Tripterygium wilfordii, G.O. Caviness, J. Ksiazek, R. Barton, J.A. Glinski.

24. Thirty fourth Meeting of the American Society of Pharmacognosy, July 18-22,

1993, San Diego CA, "Bioassay-guided isolation of Triptolide from Tripterygium

wilfordii and its biological properties" J.A. Glinski, G.O. Caviness, J. Ksiazek, M.M. O'Neill, D. Fortugno-Erikson, R.A. Jejer, J.R. Mikell, K.G. Grozinger, T.P. Parks, R. Mucci, R.W. Barton, S.D. Marlin, P.E. Lipsky, X. Tao.

25. Invited lecture. Hans Knoll Research Institute, Jena, Germany, July 22, 1993,

J.A Glinski, “Significance of plant-derived non-specific enzyme inhibitors for

antimicrobial plant defenses”.

26. Invited lecture. Second Annual IBC Conference of the Clinical and Commercial

Benefits of Medicinal Plants, Washington, D.C., September 11-12, 1995, "Plant

Secondary Metabolites: Their Natural Role versus Responses in biological Testing"

J. A. Glinski

27. Fourth International Symposium on Chromatography of Natural Products,

Lublin, Poland, “Isolation of four markers for standardization of Muira Puama

(Ptychopetalum olacoides), a South American libido-enhancing plant, by an

exclusive use of Centrifugal Partition Chromatography”, J.A. Glinski, J. Pierce,

B.Cortes, R. Deveraux, F. Poupeye.

28. International Conference on Soya Health and Nutrition, Brugges, Belgium,

Oct. 8-9, 2004, “Fractionation of Soya Saponins by Kromaton Fast Centrifugal Partion Chromatograph”, J.A. Glinski, M.A. Davey, M. Berhow.